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This process is iron-dependent and be inhibited by iron chelatorsm. 3 As a programmed death, the most important feature of ferroptosis is the peroxidation of intact cell membrane lipids, which leads to the deposition of lethal amounts of reactive oxygen species (ROS). Non-programmed cell death is caused by the direct action of physical and chemical factors and cannot be regulated, whereas programmed cell death can be regulated. The modes of cell death are mainly divided into non-programmed death and programmed death. One such process that can contribute to NP development and persistence is ferroptosis. However, the specific processes that lead to NP remain unclear. 2 To develop treatments, it is important to identify targets and their underlying disease-related mechanisms. Currently, there is no effective method for relieving NP. 1 This disease is refractory and has a complex pathogenesis that affects the quality of life of many patients. NP is chronic pain caused by lesions or disorders of the somatosensory nervous system, manifesting as spontaneous pain, hyperalgesia, and abnormal pain. Neuropathic pain (NP) is one of the most debilitating chronic pain syndromes worldwide. Keywords: neuropathic pain, regulator of G protein signaling 4, RGS4, immune infiltration, ferroptosis Ferroptosis may be the next research direction to explore NP mechanism. Key genes of RGS4 and HIF− 1 signaling pathway were screened.Ĭonclusion: This study contributes to our understanding of the neuroimmune mechanism of neuropathic pain, provides a reference for NP biomarkers and drug targets. APC co-stimulation, CCR, cytolytic activity, humid-promoting, neutrophils, NK cells, and RGS4, CXCL2, DRD4 and other 7 genes related to ferroptosis were involved in NP development. Results: We identified 224 DEGs, including 191 upregulated genes and 33 downregulated genes.

Finally, we crossed core genes with diagnostic markers and analyzed gene correlation with molecular subtypes and immune cells. We used WGCNA to identify gene co-expression modules of NP, and explored the relationship between gene networks and phenotypes. Additionally, we used the DGIdb database and correlation test to construct gene-drug and transcription factor interaction networks for differentially expressed genes relevant to NP-related ferroptosis.

According to GSEA and GSVA, NP is concentrated in a large number of immune-related pathways and genes. LASSO regression modeling was used to screen key genes to identify diagnostic gene markers. Based on the single-sample gene set enrichment analysis (ssGSEA) method, 29 immune gene sets were identified in each sample, and these samples were correlated with the immune infiltration phenotype. Methods: Data from rat spinal nerve ligations and the sham group were downloaded from the Gene Expression Omnibus (GEO) database. The purpose of this study was to identify differentially expressed genes (DEGs) and specific and meaningful gene targets for the diagnosis and treatment of NP. However, NP pathogenesis remains unclear. Yan-Hua Bi, 1 Jia Wang, 1 Zhi-Jun Guo, 2 Kai-Ning Jia 3ġNeurosurgery Department, Huabei Petroleum Administration Bureau General Hospital, Renqiu, People’s Republic of China 2Medical Imaging Department, Huabei Petroleum Administration Bureau General Hospital, Renqiu, People’s Republic of China 3Clinical Trials Center, Huabei Petroleum Administration Bureau General Hospital, Renqiu, People’s Republic of ChinaĬorrespondence: Kai-Ning Jia, Clinical Trials Center, Huabei Petroleum Administration Bureau General Hospital, Renqiu, 062550, People’s Republic of China, Email īackground: Neuropathic pain (NP) caused by a lesion or disease of the somatosensory nervous system is a common chronic pain condition that has a major impact on quality of life.

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